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Science Daily — A University of Alberta researcher has discovered a potential breakthrough for premature ejaculation–the most common sexual dysfunction in men–with a drug usually used to treat bi-polar or anxiety disorder.

Dr. Pierre Chue, a psychiatry professor at the U of A, has found success in treating premature ejaculation (PE) with the use of gabapentin, better known by the brand name Neurontin. Chue writes about his findings in the September issue of the “Canadian Journal of Psychiatry.”

“This disorder affects almost 40 per cent of males–it is even more common than erectile dysfunction–yet it is not talked about much and there has been very little research on it,” said Chue.

The essential feature of the disorder is persistent ejaculation with minimal sexual stimulation before or shortly after penetration and before the person wishes it. PE is believed to be a neurobiological phenomenon involving primarily a disturbance of serotonin receptor function. Currently, physicians prescribe medications that are known to influence these receptors–selective serotonin reuptake inhibitors or SSRIs–that delay ejaculation but these antidepressants also come with negative side-effects..

In his report, Chue cites a case study in which a 40-year-old man diagnosed with PE received minimal effectiveness from different techniques–the use of a condom with topical anesthetic and different antidepressant drugs–aimed to improve the disorder. The drugs resulted in such side effects as restless legs, headaches, decreased libido or accelerated ejaculation. The man “had previously found that alcohol produced satisfactory ejaculatory delay with no loss of erectile capacity, but clearly this was not a feasible regular option,” says Chue. A trial of gabapentin taken one to two hours before intercourse proved effective. Higher doses prolonged ejaculation even further but also caused drowsiness.

Dr. Chue is not certain how gabapentin works to improve PE but believes it has to do with the drug’s ability to increase aminobutyric acid (GABA), the most important inhibitory neurotransmitter in the brain. Since there are currently no specific treatments for PE, the use of gabepentin to prolong ejaculation warrants further study, says Chue, particularly for those men where other therapies are ineffective or poorly tolerated.

Meanwhile, Chue is looking for people to participate in a clinical trial he is running that will use an SSRI-type drug called dapoxetine, to learn its effects on men with PE. This is an SSRI with a very short half-life that has been shown in clinical trials to delay ejaculation without the usual SSRI side effects.

Note: This story has been adapted from material provided by University Of Alberta.

Originaly from: University Of Alberta Researcher Offers Promising Treatment For Premature Ejaculation
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Science Daily — HOUSTON (Oct. 7, 2004) — A deadly bacterium’s defense against a mortal molecular enemy illuminates the origins and structure of a vital protein involved in human cell signaling, University of Texas Medical School scientists report today in Science Express, the rapid online publication forum for the journal Science.

The paper also details how evolution transformed one of nature’s simplest molecules, nitric oxide (NO), from a toxin to anaerobic bacteria the planet’s oldest life form into a beneficial signaling molecule in higher animals. It also offers an explanation for how the decades-old practice of treating meat with sodium nitrite prevents life-threatening food poisoning known as botulism.

Discovering how botulism-causing Clostridium botulinum detects nitric oxide (NO) sheds light on how NO connects with its receptor protein in humans to govern crucial processes in the cardiovascular, neurological and immunological systems, said senior author C. S. Raman, Ph.D., assistant professor and director of the Structural Biology Research Center in the UT Medical School Department of Biochemistry and Molecular Biology.

“We started by identifying the protein that the botulism bug uses to detect and evade NO,” Raman said. “What we have ultimately shown is how this protein evolved from being part of a protective mechanism into a system that learned to use the toxin to benefit the organism.”

In human beings, nitric oxide binds to a receptor called soluble guanylyl cyclase to make cyclic GMP, a molecule that improves blood flow by relaxing blood vessel walls. Ferid Murad, M.D., Ph.D., professor and chairman of Integrative Biology and Pharmacology at the UT Medical School at Houston, won the Nobel prize for his 1977 finding that NO is the ingredient that makes nitroglycerine beneficial to heart patients. Since then NO has been found to govern many other vital biological functions and became the basis for medications that treat erectile dysfunction.

However, the structural details of soluble guanylyl cyclase have remained elusive, Murad and Raman said. The protein is difficult to crystallize for structural analysis.

During a series of experiments that tracked the evolutionary development of the sensor protein identified in C. botulinum, dubbed SONO for “sensor of NO,” the scientists were able to determine the three-dimensional structure of a related nitric oxide sensor in a different bacterium.

That structure will provide a key to unlock answers to some questions regarding the human NO receptor, soluble guanylyl cyclase (sGC), Raman said. “Having these structures now will help us attack that problem, because we know that this bacterial version of SONO is very similar to soluble guanylyl cyclase.

“If you know the structure of a protein, then you can develop therapeutics targeted to detect specific binding pockets on the molecule,” Raman said. “That may allow us to control sGC activity in the absence of nitric oxide in such a way that we can combat cardiovascular and cerebrovascular disease.”

And don’t forget meat protection. The research team showed that C. botulinum uses SONO to detect nitric oxide, and then to flee its presence. “It’s a strange topic for a strict vegetarian who has never touched meat in his life,” Raman said.

Co-authors of the paper are: First author Pierre Nioche, Ph.D., research fellow in the Structural Biology Research Center; Vladimir Berka, Ph.D., senior research associate and Ah-Lim Tsai, Ph.D., professor, both of the Medical School Division of Hematology; and from the United Kingdom, Julia Vipond of the Health Protection Agency, Porton Down, Salisbury; and Nigel Minton of the Center of Biomolecular Sciences and Institute of Infection, Immunity and Inflammation, University of Nottingham.

Note: This story has been adapted from material provided by University Of Texas Health Science Center At Houston. Continue reading →

By Helen Branswell

TORONTO (CP) - As you zap mounds of spam from your e-mail inbox, do you ever wonder who would be naive enough to give credit card details to the anonymous folks behind the dubiously worded drug offers?

Well, researchers from the University of Toronto did. And to their surprise they found the damn spam delivered.

Dr. Alejandro Jadad and research fellow Peter Gernburd were able to purchase products that looked like brand-name erectile dysfunction medications, anti-anxiety drugs and obesity supplements with relative ease - though what exactly is in the bubble packs remains to be seen.

But Jadad, a researcher who describes himself as a public advocate, warned the business is a shady one. An address used to purchase medication one week can be a dead end the next, leaving buyers with no recourse if the drugs turn out to be bogus or past their expiry date.

“These could be fake. These could be real. These could be adulterated. We don’t know,” Jadad said of the products he and Gernburd managed to purchase.

“So ‘User beware’ big time here.”

“The message really is not ‘Oh, you’re going to get it.’ The message is you’re going to get things from places that you don’t know, that are not responsible, that disappear, and that are breaking the law. So be very careful.”

The researchers are in the process of having the products analyzed by a laboratory.

Health Canada would not offer comment Monday on Jadad’s study, which was published Tuesday in the journal Public Library of Science Medicine.

Instead, a spokesperson pointed to cautions posted on the department’s website, statements warning that people put their health at serious risk when they buy drugs online.

“You have no way of knowing where these companies are located, where they get their drugs, what is in their drugs, or how to reach them if there is a problem,” the department says in a fact sheet posted on its website.

“If you order from these sites, you may get counterfeit drugs with no active ingredients, drugs with the wrong ingredients, drugs with dangerous additives, or drugs past their expiry date. Even if these drugs do not harm you directly or immediately, your condition may get worse without effective treatment.”

Jadad was inspired to explore the business of spam-generated drug sales because of the volume of the unwanted e-mail he was getting himself.

A check of the medical literature produced little on the subject. So he and Gernburd set up three e-mail accounts and monitored the number and types of spam messages they received.

In one month - November 2006 - the accounts received 4,153 messages what qualified as spam, 82 per cent of the total e-mail traffic. Health-related spam made up 32 per cent of the total.

As far as the researchers could tell, most was from abroad - the United States, China and the Democratic Republic of Congo. Only 58 per cent of the active links in the spam e-mails were still viable a week later and only a quarter of the links still worked at the end of the month.

Jadad’s wife had secured a special credit card with a low credit limit and Jadad and Gernburd tried to order 27 items using it.

Only nine orders went through. Five were for prescription drugs (erectile dysfunction drugs and anti-anxiety medications) and four were for natural health products (weight management and penile enlargement).

The only charges made against the credit card were for items that were actually delivered, Jadad said. But whether the products are the real thing remains to be seen.

He wouldn’t say if the drugs were expired or more expensive than they would have been in a local pharmacy, saying that analysis will be in a future instalment of this work.

While some might worry that this study would actually give people confidence they can buy drugs from spammers, Jadad said it’s important to know what’s going on in this netherworld, because people clearly are accessing prescription drugs this way.

“The fact at the end of the day is … there are enough people who are willing to look at those messages and consider the products and make an order. And that is what keeps this going,” said Jadad, a professor of medicine at the University of Toronto and founder of the Centre for Global eHealth Innovation at Toronto’s University Health Network.

“If people didn’t respond, we wouldn’t have spam. And the fact that spam is growing so much is a reflection of the fact that the spammers are making a lot of money out of it.”
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BioLife Remedies, Inc. is pleased to announce that DIA-X™ is now available for retail and wholesale at www.blfrproducts.com. DIA-X™ is an herbal product developed by the company for men with Erectile Dysfunction from Diabetes.

Vancouver, B.C. and Guangzhou, China (PRWEB) May 29, 2007 — BioLife Remedies, Inc. announces the opening of sales of Dia-X(former name Di-Agra) for the remedy of Erectile Dysfunction for Diabetics.

BioLife Remedies, Inc. (PINKSHEETS: BLRS) is pleased to announce that DIA-X™ is now available for retail and wholesale at www.blfrproducts.com. DIA-X™ is an herbal product developed by the company for men with Erectile Dysfunction from Diabetes.

The President and CEO of the Company, Jack Guo commented, "DIA-X™ is developed for diabetic male with E.D., and the product was derived from a century-old TCM herbal formula used traditionally for men with Diabetes Mellitus who have problems in their sexual activity. Our researchers did extensive studies and tests on the formula and identified the herbs that are effective in getting and keeping an erection for sexual activity while helping people to control blood glucose level."

Mr. Jack Guo also commented, "If the diabetic men have developed symptoms of Erectile Dysfunction, it seems that other symptoms of complication may also be presented, such as frequent urination, so we suggest customers to taking Dia-X and Zutrol together for more effective recovery of health." For more information of the products, please visit www.blfrproducts.com.

About BioLife Remedies, Inc
Biolife Remedies, Inc. combines Traditional Chinese Medicine and Western academic research and development practices with the newest scientific technology to produce effective medical and health-care products to combat serious diseases. The BioLife Group has developed 108 master medical formulas to treat various diseases including diabetes, prostateria, osteoporosis, cerebrovascular disease, cardiac vascular disease, hypertension, menopausal syndrome, and sexual disorders in men and women. For further information about BioLife Remedies Inc. please refer to its Web site at http://www.blfrproducts.com

Contact:
BioLife Remedies,Inc
Jack Guo
http://www.blfrproducts.com
Tel: 604-630-8881
Fax: 604-630-8877

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NEW YORK (Reuters Health) - An expanding waistline in older men is associated with worsening lower urinary tract symptoms and poorer sexual function, according to research reported at the American Urological Association meeting in Anaheim.

At a press briefing, Dr. Steven A. Kaplan from Weill Cornell Medical College, New York, noted that waist size is one component of the so-called metabolic syndrome, which signifies an elevated risk of heart disease and diabetes. "It is becoming very clear that when you have multiple components of the metabolic syndrome you can bet that you will have components of pelvic dysfunction, which we would define as sexual dysfunction and voiding dysfunction," Kaplan said.

He and his colleagues tested the idea that waist circumference may be a useful predictor of prostate volume and the severity of pelvic dysfunction.

They grouped 88 men (average age, 62 years) with moderate or severe untreated voiding symptoms by waist circumference: 30-36 inches, 36-40 inches, and more than 40 inches.

Increasing waist circumference was significantly associated with "every parameter we looked at," Kaplan said. Prostate volume, PSA level, voiding symptom score, erectile dysfunction, and ejaculatory dysfunction all increased as waist size increased, he explained.

"The results were simply remarkable. They even surprised us," he commented. "We have no doubt, at least from this cohort of patients, that increasing waist circumference is associated with worsening male health — voiding and sexual function."

This study, Kaplan concluded, shows that obese men are at increased risk of pelvic dysfunction and can be "easily diagnosed" by measuring waist circumference. Continue reading →

ANCHORAGE, Alaska - A man who once agreed to help conserve fur seals has pleaded guilty to illegally selling their parts.

Michael Richard Zacharof, former president of the Aleut Community of St. Paul Island Tribal Government, co-signed an agreement with the National Marine Fisheries Service in 2000 to help manage northern fur seals. Northern fur seals are designated a "depleted species" under the Marine Mammal Protection Act.

Zacharof, 50, of St. Paul Island, entered his plea by telephone in a hearing held Tuesday in U.S. District Court in Anchorage. St. Paul Island is located about 300 miles west of the Alaska mainland in the Bering Sea. Its 460 residents are mostly Eskimo or Aleut.

Zacharof faces up to one year in prison and a $20,000 fine for selling seal parts when he is sentenced in the fall.

A call to his home on St. Paul Island was not immediately returned.

Federal prosecutors say Zacharof illegally sold more than 100 seal penises to a Korean gift shop in Anchorage, where they were to be resold for about $100 apiece in the traditional Chinese medicine trade.

Seal penis bones, also called oosiks, are sometimes believed to work like erectile dysfunction drugs, Assistant U.S. Attorney Aunnie Steward said.

The investigation began in Massachusetts in 2004 when bear gall bladders and seal oosiks were discovered in a Boston suburb. The sales were traced to the Korean gift shop in Anchorage. From there, the parts were traced to Zacharof, an Alaska Native who headed a seal hunt, Steward said.

"They (Alaska Natives) are allowed to do this for subsistence purposes and they also are allowed to convert different parts of the seal to traditional Native handicrafts," she said. "They can't sell raw unworked marine mammal parts of any kind."

Steward said the gift shop also faces prosecution.

Kevin Heck, assistant special agent in charge of fisheries enforcement for the National Oceanic and Atmospheric Administration in Anchorage, said the agency was surprised to discover the scope of the market in seal oosiks.

Such cases are difficult to prosecute for a number of reasons, including the remoteness of St. Paul Island, Heck said.

St. Paul, which is part of the Pribilof Islands, was discovered by Russian fur traders in the 1780s. Fur seals subsequently were severely overharvested. Continue reading →

CHICAGO (Reuters) - The type of prostate cancer treatment a man gets has a lot to do with the kind of specialist he sees first, according to a study released on Monday that lends scientific evidence to something many men have likely guessed.

Prostate cancer can be treated effectively using radiation, radioactive seeds or surgical removal of the prostate. Surgery or drugs to stop production of testosterone, known as hormone therapy, may also be used in high-risk patients.

Doctors often also advise close medical observation, also known as watchful waiting.

Each treatment is associated with different benefits and side effects. Prostate surgery can cause urinary incontinence and erectile dysfunction; radiation therapy can cause diarrhea and erectile dysfunction; and hormone therapy can cause hot flashes and breast tenderness.

"You want your physician to convey this information without a bias," Dr. Thomas Jang, a urologist from Memorial Sloan-Kettering Cancer Center in New York, said at the annual meeting of the American Society of Clinical Oncologists.

Although the 5-year survival rate for men with localized prostate cancer is nearly 100 percent, it is the third most common cause of cancer death in men of all ages, and the most common cause of cancer death in men over 75.

No scientific studies have proven which therapy works best, so men typically follow their doctor's recommendation, said Jang.

The study of more than 85,000 men aged 65 and older with prostate cancer that had not yet spread uncovered a strong correlation between physician type and treatment.

If a man's doctor happens to be a urologist, for example, the recommendation for men under 70 most often will be surgery — 70 percent of the time. For men over 75 who saw only a urologist, the choice was watchful waiting or hormone therapy in 91 percent of the patients.

But if they saw both a urologist and a radiation oncologist, 78 percent of younger men and 85 percent of older men got radiation therapy.

Because patients tend to fare well on all the treatment options, the choice comes down to which side effects and treatment options best fit the patient, Dr. Justin Bekelman, a radiation oncologist at Memorial Sloan-Kettering, who worked on the study, said in an interview.

"It's not enough to say, Google it and check it out," he said.

Most prostate cancer patients tend to see a urologist first because they are the doctors who perform biopsies and make diagnoses.

"I think urologists as gatekeepers have to present balanced information," Jang said.

The American Cancer SocietyP.S.

American Cancer Society expects 218,890 U.S. men to be diagnosed with prostate cancer in 2007 and 27,000 to die of it.

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NEW YORK (Reuters Health) - Laboratory studies conducted at Queen's University Belfast, UK suggest that taking the erectile dysfunction drug Viagra may adversely affect sperm function and possibly male fertility.

Recreational users of Viagra need to be informed of the drug's potentially harmful effects on sperm function, the investigators say.

In their experiments, Dr. David R. J. Glenn and colleagues observed that exposure of cultured sperm to Viagra, compared to no exposure, led to a "sustained enhancement of motility," both in numbers of progressively motile sperm and their velocity.

However, exposure to Viagra — at concentrations equivalent to the average maximum total blood concentration present 30 minutes after a single oral dose of 100 milligrams — also caused a premature "acrosome reaction." Acrosomes are structures that cover the head of the sperm and contain a variety of enzymes that help the sperm penetrate the outer membrane of the egg.

That Viagra may induce early activation of the acrosome reaction has "important clinical implications because sperm that acrosome-react before contact with the oocyte are incapable of fertilization," the researchers note in the journal Fertility and Sterility.

"Given that the majority of sperm acrosome react on exposure to (Viagra), the drug may cause significant impairment to their fertilizing potential," they write.

This is a concern, Glenn and colleagues say, given that Viagra and other like-drugs are widely available on the Internet and are increasingly being used "recreationally" by young healthy men of reproductive age as sexual enhancers — not just by older men who have erectile dysfunction.

SOURCE: Fertility and Sterility, May 2007. Continue reading →

Pelvic floor exercises have long been recommended for women - now researchers say they could help men too.

The exercises were found to help men with erectile dysfunction as much as taking in Viagra.

The researchers say the findings mean men have an alternative to drug therapy.

For around 50 years, women have been advised to perform pelvic floor exercises to strengthen their muscles for childbirth.

The pelvic floor is a "hammock" of muscles which support the bowel and bladder.

Pelvic floor, or Kegel, exercises involve clenching the muscles you would use to prevent yourself urinating.

This latest research indicates it is also important for men to maintain the muscle tone and function of their pelvic floor muscles with the exercises.

Home exercises

The team from the University of the West of England in Bristol studied 55 men with an average age of 59 who had experienced erectile dysfunction for at least six months.

The men, all patients at the Somerset Nuffield Hospital, Taunton, Somerset, were given five weekly sessions of pelvic floor exercises and assessed at three and six months, and asked to practise the exercises daily at home.

It was found 40% of the men regained normal erectile function - some of who had severe erectile dysfunction, and another 35% showed some improvement.

Two thirds of the men had said they also had problems with urination. These improved significantly after they began the exercises.

Dr Grace Dorey, a specialist continence physiotherapist who carried out the research, told BBC News Online: "The exercises were found to be equally as effective as taking Viagra.

"Pelvic floor exercises improve function in a physical way, in a more natural way.

"Men should be doing preventative exercise. It really is use it or lose it."

She said men should be exercising their pelvic floor exercises from puberty onwards.

Strength

A spokesperson for the Impotence Association said: "The value and effectiveness of pelvic floor exercises should not be underestimated when considering the management of sexual problems such as impotence and premature ejaculation.

"The exercises are thought to strengthen the muscles that surround the penis and improve the blood supply in the pelvis, which is an important factor in relation to erectile dysfunction."

The Impotence Association helpline number is 0208 767 7791.

Originaly from Source